| 1 | Fox Raceway at Pala | Pala, California | 2022-05-28 | 450: Chase Sexton, 250: Jett Lawrence |
| 2 | Hangtown Motocross Classic | Rancho Cordova, California | 2022-06-04 | 450: Jason Anderson, 250: Jett Lawrence |
| 3 | Thunder Valley Motocross Park | Lakewood, Colorado | 2022-06-11 | 450: Ken Roczen, 250: Jett Lawrence |
| 4 | High Point Raceway | Mount Morris, Pennsylvania | 2022-06-18 | 450: Eli Tomac, 250: Jett Lawrence |
| 5 | Red Bud MX | Buchanan, Michigan | 2022-07-02 | 450: Eli Tomac, 250: Jo Shimoda |
| 6 | The Wick 338 | Southwick, Massachusetts | 2022-07-09 | 450: Eli Tomac, 250: Jett Lawrence |
| 7 | Spring Creek MX Park | Millville, Minnesota | 2022-07-16 | 450: Eli Tomac, 250: Jett Lawrence |
| 8 | Washougal MX Park | Washougal, Washington | 2022-07-23 | 450: Chase Sexton, 250: Jett Lawrence |
| 9 | Unadilla MX | Unadilla, New York | 2022-08-13 | 450: Chase Sexton, 250: Jo Shimoda |
| 10 | Budds Creek Motocross Park | Mechanicsville, Maryland | 2022-08-20 | 450: Jason Anderson, 250: R.J. Hampshire |
| 11 | Ironman Raceway | Crawfordsville, Indiana | 2022-08-27 | 450: Chase Sexton, 250: Jett Lawrence |
| 12 | Fox Raceway at Pala | Pala, California | 2022-09-03 | 450: Eli Tomac, 250: Jett Lawrence |