| 1 | Fox Raceway at Pala | Pala, California | 2021-05-29 | 450: Dylan Ferrandis, 250: Jett Lawrence |
| 2 | Thunder Valley Motocross Park | Lakewood, Colorado | 2021-06-05 | 450: Ken Roczen, 250: Justin Cooper |
| 3 | High Point Raceway | Mount Morris, Pennsylvania | 2021-06-19 | 450: Dylan Ferrandis, 250: Jalek Swoll |
| 4 | Red Bud MX | Buchanan, Michigan | 2021-07-03 | 450: Dylan Ferrandis, 250: R.J. Hampshire |
| 5 | The Wick 338 | Southwick, Massachusetts | 2021-07-10 | 450: Dylan Ferrandis, 250: Hunter Lawrence |
| 6 | Spring Creek MX Park | Millville, Minnesota | 2021-07-17 | 450: Justin Barcia, 250: Jeremy Martin |
| 7 | Washougal MX Park | Washougal, Washington | 2021-07-24 | 450: Chase Sexton, 250: Jeremy Martin |
| 8 | Unadilla MX | Unadilla, New York | 2021-08-14 | 450: Ken Roczen, 250: Jett Lawrence |
| 9 | Budds Creek Motocross Park | Mechanicsville, Maryland | 2021-08-21 | 450: Dylan Ferrandis, 250: Jeremy Martin |
| 10 | Ironman Raceway | Crawfordsville, Indiana | 2021-08-28 | 450: Eli Tomac, 250: Jett Lawrence |
| 11 | Fox Raceway at Pala | Pala, California | 2021-09-04 | 450: Eli Tomac, 250: Jett Lawrence |
| 12 | Hangtown Motocross Classic | Rancho Cordova, California | 2021-09-11 | 450: Dylan Ferrandis, 250: Justin Cooper |