| 1 | NRG Stadium | Houston, Texas | 2021-01-16 | 450: Justin Barcia, 250: Christian Craig |
| 2 | NRG Stadium | Houston, Texas | 2021-01-19 | 450: Eli Tomac, 250: Jett Lawrence |
| 3 | NRG Stadium | Houston, Texas | 2021-01-23 | 450: Cooper Webb, 250: Colt Nichols |
| 4 | Lucas Oil Stadium | Indianapolis, Indiana | 2021-01-30 | 450: Ken Roczen, 250: Colt Nichols |
| 5 | Lucas Oil Stadium | Indianapolis, Indiana | 2021-02-02 | 450: Ken Roczen, 250: Colt Nichols |
| 6 | Lucas Oil Stadium | Indianapolis, Indiana | 2021-02-06 | 450: Ken Roczen, 250: Christian Craig |
| 7 | Camping World Stadium | Orlando, Florida | 2021-02-13 | 450: Cooper Webb, 250: Jett Lawrence |
| 8 | Camping World Stadium | Orlando, Florida | 2021-02-20 | 450: Cooper Webb, 250: Justin Cooper |
| 9 | Daytona International Speedway | Daytona, Florida | 2021-03-06 | 450: Eli Tomac, 250: Cameron McAdoo |
| 10 | AT&T Stadium | Arlington, Texas | 2021-03-13 | 450: Cooper Webb, 250: Seth Hammaker |
| 11 | AT&T Stadium | Arlington, Texas | 2021-03-16 | 450: Cooper Webb, 250: Hunter Lawrence |
| 12 | AT&T Stadium | Arlington, Texas | 2021-03-20 | 450: Cooper Webb, 250: Justin Cooper |
| 13 | Atlanta Motor Speedway | Hampton, Georgia | 2021-04-10 | 450: Eli Tomac, 250: Nate Thrasher |
| 14 | Atlanta Motor Speedway | Hampton, Georgia | 2021-04-13 | 450: Ken Roczen, 250: Justin Cooper |
| 15 | Atlanta Motor Speedway | Hampton, Georgia | 2021-04-17 | 450: Cooper Webb, 250: Nate Thrasher |
| 16 | Rice-Eccles Stadium | Salt Lake City, Utah | 2021-04-24 | 450: Marvin Musquin, 250: Jo Shimoda |
| 17 | Rice-Eccles Stadium | Salt Lake City, Utah | 2021-05-01 | 450: Cooper Webb, 250: Jett Lawrence |